Common reaction types substitution addition elimination and rearrangement - One Line Questions

1. What is the primary product when ethene reacts with HBr? — 1-bromoethane
2. What is the main product when tert-butyl bromide reacts with sodium hydroxide in aqueous solution? — tert-butyl alcohol
3. An E2 reaction requires: — A strong base and a specific stereochemical orientation
4. The conversion of an alkane to an alkene by removing two hydrogen atoms is an example of: — Dehydrogenation (a type of elimination)
5. Which reaction involves the migration of an alkyl or aryl group from one atom to another within the same molecule? — Rearrangement
6. The reaction where a nucleophile replaces a leaving group on a saturated carbon atom is called: — Substitution
7. The reaction of an alkene with ozone followed by a reducing agent (ozonolysis) is a type of: — Addition
8. The rate of an SN2 reaction is dependent on the concentration of: — Alkyl halide and nucleophile
9. In an elimination reaction, what is typically removed from a molecule? — Two atoms or groups from adjacent carbons
10. Which of the following is an example of electrophilic substitution? — Benzene reacting with Br2 in the presence of FeBr3
11. Which mechanism is most commonly associated with SN2 reactions? — Concerted, single-step process
12. Which of the following reactions is an example of a rearrangement? — The conversion of 2-methyl-2-butanol to 2-methyl-1-butene under acidic conditions
13. The pinacol rearrangement involves the acid-catalyzed rearrangement of: — 1,2-diols
14. Which of the following is a classic example of a nucleophilic substitution reaction? — Ethyl bromide reacting with hydroxide ion
15. Which of the following is a characteristic of SN1 reactions? — First-order kinetics
16. Which of the following is a characteristic of E1 reactions? — First-order kinetics
17. Electrophilic addition to alkenes typically involves: — Formation of a carbocation intermediate
18. What is the driving force for many elimination reactions? — Formation of a more stable alkene
19. The reaction of a primary alkyl halide with sodium ethoxide in ethanol can lead to both substitution and elimination. Which condition favors elimination? — High temperature and a more concentrated solution
20. In the reaction of an alkyl halide with alcoholic KOH, the major product is usually the most substituted alkene according to: — Zaitsev's Rule
21. In a free radical substitution reaction, which species initiates the chain mechanism? — Free radical
22. The addition of a halogen to an alkyne typically occurs in how many steps? — Two steps, forming a tetrahalide
23. Which of the following is NOT a common type of rearrangement reaction? — Diels-Alder reaction
24. Which rearrangement reaction involves the conversion of a ketone to an amide in the presence of sulfuric acid? — Beckmann rearrangement
25. Which of the following conditions favors elimination reactions over substitution reactions? — Secondary or tertiary alkyl halide and a strong, bulky base
26. Which of the following is a characteristic of SN2 reactions? — Inversion of configuration
27. Which of the following is an example of nucleophilic addition? — Reaction of a ketone with HCN
28. Which of the following is a characteristic of addition reactions to alkenes? — Saturation of the molecule
29. A carbocation intermediate is typically formed in which type of substitution reaction? — SN1
30. The Walden inversion is a characteristic feature of which substitution reaction? — SN2
31. Which reaction involves the simultaneous removal of a leaving group and a proton from adjacent carbons? — E2
32. A molecular rearrangement where a carbocation loses a proton is characteristic of which reaction type? — E1
33. The reaction of a tertiary alkyl halide with a weak nucleophile in a protic solvent will likely proceed via: — SN1 mechanism
34. Which type of reaction involves the breaking of a pi bond and the formation of two new sigma bonds? — Addition
35. The reaction of an alkene with a halogen (e.g., Br2) in the absence of a solvent is an example of: — Addition
36. Which type of reaction is represented by the conversion of 2-bromopropane to propene? — Elimination
37. The reaction of an alcohol with a strong acid (like H2SO4) at high temperature to form an alkene is an example of: — Elimination
38. The reaction of an alkyl halide with a strong base like KOH in ethanol at reflux temperature primarily leads to: — Elimination
39. Dehydrohalogenation of alkyl halides is a type of: — Elimination
40. Which type of reaction leads to the formation of a more unsaturated compound from a less unsaturated one? — Elimination
41. The reaction of an alkene with KMnO4 under mild conditions (Baeyer's test) is an example of: — Oxidation (a type of addition)
42. The reaction of ethene with water in the presence of sulfuric acid is an example of: — Addition
43. Which reaction type is primarily responsible for the synthesis of alkenes from alcohols? — Elimination
44. The reaction of an aldehyde or ketone with a Grignard reagent is an example of: — Addition
45. Which reaction type involves the formation of a new sigma bond by breaking a pi bond? — Addition
46. The Fiest-Benary furan synthesis is an example of a reaction that involves: — Cyclization and elimination
47. The addition of Br2 to cyclohexene results in: — Anti addition
48. The addition of a hydrogen halide to an unsymmetrical alkene follows Markovnikov's rule, meaning the hydrogen atom adds to: — The carbon with more hydrogen atoms
49. A rearrangement reaction is characterized by: — A change in the carbon skeleton of the molecule
50. The addition of H2O to an alkene in the presence of an acid catalyst follows which rule for regioselectivity? — Markovnikov's Rule
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